Dear colleagues, Data on sequence level mapping through the SIFTS process <https://www.ebi.ac.uk/pdbe/docs/sifts/> can now be retrieved directly from updated mmCIF files, available on PDBe entry pages. These files now contain residue-level mapping between UniProt and PDB entries, including coordinate numbering for UniProt accessions and mapping to a host of other protein resources. PDBe’s release process creates ‘updated’ PDBx/mmCIF files from PDB archive files, containing remapped enumerations and additional information, while yielding more consistent, standardised metadata, without altering core PDB information, such as atomic coordinates and experimental data. These updated PDBx/mmCIF files have now been further enriched by the addition of three new ‘SIFTS- specific’ categories, providing improved mapping between structure and sequence data. SIFTS provides residue-level mapping between UniProt and PDB entries, while also incorporating annotation from the IntEnz, GO, InterPro, Pfam, CATH, SCOP, SCOP2, PubMed, Ensembl and Homologene resources. The information is updated and released every Wednesday concurrently with the release of new PDB entries and can be obtained from the PDBe Rest API <https://www.ebi.ac.uk/pdbe/api/doc/sifts.html> or PDB entry XML files in the EMBL-EBI FTP <ftp://ftp.ebi.ac.uk/pub/databases/msd/sifts/> area. Following this update to the updated PDBx/mmCIF files produced by PDBe, SIFTS data can also be directly retrieved from these files and are available from PDBe entry pages. For more information, visit https://www.ebi.ac.uk/pdbe/about/news/sifts-data-now-included-pdbe-mmcif-files Kind Regards, David Armstrong -- David Armstrong Outreach and Training Coordinator PDBe European Bioinformatics Institute (EMBL-EBI) European Molecular Biology Laboratory Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SD UK Tel: +44 1223 492544