More than 1, 000 SARS-CoV-2 Coronavirus Protein Structures Available

JY
Jasmine Young
Wed, Mar 3, 2021 3:35 PM

With this week's update, 1,018 SARS-CoV-2-related structures are now
freely available from the Protein Data Bank.

The first SARS-CoV-2 structure, a high-resolution crystal structure of
the coronavirus main protease (PDB 6lu7
http://www.wwpdb.org/pdb?id=pdb_00006lu7), was released early in the
pandemic on February 5, 2020.

Since then, structural biologists have visualized most of the SARS-CoV-2
proteome, including the spike protein binding to its ACE2 receptor and
neutralizing antibodies, and the main protease, the papain-like
proteinase, and other promising drug discovery targets. All of the
structures and related data are available for exploration from wwPDB
partner websites: RCSB PDB <https://urldefense.com/v3/http://rcsb.org/covid19;!!Mih3wA!X9FCIyMAub_rgODsq6aSLXUAYblcnT7HhsE8juHIU4_yi4edN4r15EkOGlzcnN8$ >, PDBe
<https://urldefense.com/v3/https://www.ebi.ac.uk/pdbe/covid-19;!!Mih3wA!X9FCIyMAub_rgODsq6aSLXUAYblcnT7HhsE8juHIU4_yi4edN4r15EkOP8Y5yHs$ >, PDBj
<https://urldefense.com/v3/https://pdbj.org/featured/covid-19?tab=all;!!Mih3wA!X9FCIyMAub_rgODsq6aSLXUAYblcnT7HhsE8juHIU4_yi4edN4r15EkO6nwV8GM$ >, and BMRB
<https://urldefense.com/v3/https://bmrb.io/coronavirus.shtml;!!Mih3wA!X9FCIyMAub_rgODsq6aSLXUAYblcnT7HhsE8juHIU4_yi4edN4r15EkObyHMs5o$ >.

Rapid public release of SARS-CoV-2 structure data has greatly increased
our understanding of Covid-19, allowed direct visualization of emerging
variants of the virus, and facilitated structure-guided drug discovery
and reuse to combat infection. Open access to PDB structures has already
enabled design of effective vaccines against SARS-CoV-2.

The response of the research community to the pandemic has highlighted
the importance of open access to scientific data in real time. The wwPDB
strives to ensure that 3D biological structure data remain freely
accessible for all, while maintaining as comprehensive and accurate an
archive as possible.

The impact of these 1018 structures and many more coronavirus protein
structures to come stands as a testament to the importance of open
access to structural biology research data.

See Illustration by David S. Goodsell, RCSB Protein Data Bank; doi:
10.2210/rcsb_pdb/goodsell-gallery-024
<https://urldefense.com/v3/http://pdb101.rcsb.org/sci-art/goodsell-gallery/respiratory-droplet;!!Mih3wA!X9FCIyMAub_rgODsq6aSLXUAYblcnT7HhsE8juHIU4_yi4edN4r15EkOR_oQ1dY$ >

--
Regards,

Jasmine

---==========================
Jasmine Young, Ph.D.
Biocuration Team Lead
RCSB Protein Data Bank
Research Professor
Institute for Quantitative Biomedicine
Rutgers, The State University of New Jersey
174 Frelinghuysen Rd
Piscataway, NJ 08854-8087

Email: jasmine@rcsb.rutgers.edu
Phone: (848)445-0103 ext 4920
Fax: (732)445-4320

---==========================

With this week's update, 1,018 SARS-CoV-2-related structures are now freely available from the Protein Data Bank. The first SARS-CoV-2 structure, a high-resolution crystal structure of the coronavirus main protease (PDB 6lu7 <http://www.wwpdb.org/pdb?id=pdb_00006lu7>), was released early in the pandemic on February 5, 2020. Since then, structural biologists have visualized most of the SARS-CoV-2 proteome, including the spike protein binding to its ACE2 receptor and neutralizing antibodies, and the main protease, the papain-like proteinase, and other promising drug discovery targets. All of the structures and related data are available for exploration from wwPDB partner websites: RCSB PDB <https://urldefense.com/v3/__http://rcsb.org/covid19__;!!Mih3wA!X9FCIyMAub_rgODsq6aSLXUAYblcnT7HhsE8juHIU4_yi4edN4r15EkOGlzcnN8$ >, PDBe <https://urldefense.com/v3/__https://www.ebi.ac.uk/pdbe/covid-19__;!!Mih3wA!X9FCIyMAub_rgODsq6aSLXUAYblcnT7HhsE8juHIU4_yi4edN4r15EkOP8Y5yHs$ >, PDBj <https://urldefense.com/v3/__https://pdbj.org/featured/covid-19?tab=all__;!!Mih3wA!X9FCIyMAub_rgODsq6aSLXUAYblcnT7HhsE8juHIU4_yi4edN4r15EkO6nwV8GM$ >, and BMRB <https://urldefense.com/v3/__https://bmrb.io/coronavirus.shtml__;!!Mih3wA!X9FCIyMAub_rgODsq6aSLXUAYblcnT7HhsE8juHIU4_yi4edN4r15EkObyHMs5o$ >. Rapid public release of SARS-CoV-2 structure data has greatly increased our understanding of Covid-19, allowed direct visualization of emerging variants of the virus, and facilitated structure-guided drug discovery and reuse to combat infection. Open access to PDB structures has already enabled design of effective vaccines against SARS-CoV-2. The response of the research community to the pandemic has highlighted the importance of open access to scientific data in real time. The wwPDB strives to ensure that 3D biological structure data remain freely accessible for all, while maintaining as comprehensive and accurate an archive as possible. The impact of these 1018 structures and many more coronavirus protein structures to come stands as a testament to the importance of open access to structural biology research data. See Illustration by David S. Goodsell, RCSB Protein Data Bank; doi: 10.2210/rcsb_pdb/goodsell-gallery-024 <https://urldefense.com/v3/__http://pdb101.rcsb.org/sci-art/goodsell-gallery/respiratory-droplet__;!!Mih3wA!X9FCIyMAub_rgODsq6aSLXUAYblcnT7HhsE8juHIU4_yi4edN4r15EkOR_oQ1dY$ > -- Regards, Jasmine =========================================================== Jasmine Young, Ph.D. Biocuration Team Lead RCSB Protein Data Bank Research Professor Institute for Quantitative Biomedicine Rutgers, The State University of New Jersey 174 Frelinghuysen Rd Piscataway, NJ 08854-8087 Email: jasmine@rcsb.rutgers.edu Phone: (848)445-0103 ext 4920 Fax: (732)445-4320 ===========================================================