Dear Colleagues, PDBe has madePDBx/mmCIF files, containing SIFTS mapping information and additional, standardised metadata available directly from the EMBL-EBI FTP area, from: https://ftp.ebi.ac.uk/pub/databases/msd/updated_mmcif/ PDBe’s release process creates these enriched PDBx/mmCIF files from PDB archive files, containing more consistent, standardised metadata, without altering core PDB information, such as atomic coordinates and experimental data. These PDBx/mmCIF files have recently been further enriched with data from the SIFTS process <https://www.ebi.ac.uk/pdbe/about/news/sifts-data-now-included-pdbe-mmcif-files>, providing improved mapping between structure and sequence data. These enriched PDBx/mmCIF files are compressed and distributed from two subfolders in the FTP area. Firstly, you can efficiently access files for individual entries via the ‘divided’ folder, where each entry is placed within a folder identified by the second and third characters of the PDB entry ID (e.g. divided/at/1atp_updated.cif.gz). Alternatively, all the compressed updated PDBx mmCIF files in the PDB archive are available from the ‘all’ folder (e.g. all/1atp_updated.cif.gz). Alternatively, these files can also be downloaded from PDBe entry pages (https://www.ebi.ac.uk/pdbe/entry-files/download/7o9f_updated.cif). These files are also accessible via static URL (https://www.ebi.ac.uk/pdbe/static/entry/7o9f_updated.cif) or via PDBe bulk download service available at https://www.ebi.ac.uk/pdbe/download/api. If you have any queries about these files or how to access them, please contact our helpdesk at pdbdep@ebi.ac.uk. Kind Regards, David Armstrong -- David Armstrong Outreach and Training Coordinator PDBe European Bioinformatics Institute (EMBL-EBI) European Molecular Biology Laboratory Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SD UK Tel: +44 1223 492544