Throughout 2021, the wwPDB will be celebrating the 50th anniversary of the PDB archive (http://wwpdb.org/pdb50). The inaugural symposium will be held virtually on May 4-5, 2021. The online sessions will take place between 11 a.m. – 4:30 p.m. ET each day. The event will be recorded and made available to registered participants after the meeting. Students and postdoctoral fellows are especially encouraged to attend and will be eligible for poster awards. Register at https://urldefense.com/v3/__https://www.asbmb.org/meetings-events/pdb50__;!!Mih3wA!UskWDGRqwXoKFr8g6VdYQoQtVAEeJ3wWeUVoyf0uXaalxL8fmik4DqQP_KYwGok$ by March 15 for reduced rates. Speakers Using HIV-1 reverse transcriptase structures to guide anti-AIDS drug discovery Edward Arnold, Rutgers, The State University of New Jersey The evolution of the Protein Data Bank as a community resource Helen M. Berman, Rutgers, The State University of New Jersey and University of Southern California A personal history of five decades of structural biology and the PDB: From the X-ray structure of 2-Zinc insulin hexamer in 1970 to Cryo-EM structures of DNA-PK from DNA repair in 2020 Thomas L. Blundell, University of Cambridge Solving 3D puzzles by integrative modelling using PDB structures Alexandre M. J. J. Bonvin, Utrecht University Impact of structural biologists and fifty years of Protein Data Bank operations on drug discovery and development Stephen K. Burley, Rutgers, The State University of New Jersey and University of California, San Diego Cryo-EM of biomolecules at Ångström resolutions Wah Chiu, Stanford University 50 years of PDB — from crazy idea to treasure Johann Deisenhofer, University of Texas Southwestern Medical Center Structural biology of telomerase Juli Feigon, University of California, Los Angeles Integrated BioNMR — getting by with a little help from my friends Angela Gronenborn, University of Pittsburgh Science, crystallography, reflections: A journey with the PDB over 35 years Jennifer L. Martin, University of Wollongong Antibody small molecule conjugates with computationally designed target binding synergy Stephen L. Mayo, California Institute of Technology Structural insight into SARS-CoV-2 replication and transcription complex (RTC) Zihe Rao, ShanghaiTech University and Tsinghua University "Speck"tacular inflammasomes: structures of supramolecular complexes in innate immunity Hao Wu, Harvard Medical School, Boston Children's Hospital