Displaying detailed RNA secondary structure at PDBe entry pages

DA
David Armstrong
Thu, Mar 23, 2023 2:32 PM

**

Dear pdb-l, We have now updated the RNA two-dimensional (2D) topology
component on the PDBe pages, building on the original implementation
introduced in 2022
https://www.ebi.ac.uk/pdbe/news/rna-topology-viewer-added-pdbe-pages.
This updated component now features base pairing information,
emphasising the presence of secondary structure elements like helical
stems and single-stranded loops. This enhancement was developed and
integrated into the PDBe RNA topology viewer by Holly McCann and Caeden
Meade, collaborators from Georgia Tech. Base pairing information is
generated using the open-source FR3D software
http://europepmc.org/article/MED/21515634and incorporated into the
PDBe's weekly release process with assistance from partners at Bowling
Green State University (BGSU) https://www.bgsu.edu/.

The open-source RNA 2D topology component, available at
https://github.com/PDBeurope/pdb-rna-viewer
https://github.com/PDBeurope/pdb-rna-viewer, presents the secondary
structure in consistent, reproducible, and easily recognisable layouts
using R2DT https://nature.com/articles/s41467-021-23555-5. Base
pairing annotations are superimposed on the R2DT-generated layouts,
employing the Leontis-Westhof base-pairing classification
https://europepmc.org/article/MED/11345429. Furthermore, the component
interacts with the Mol* viewer allowing features in the 2D topology
component to be easily explored in 3D.

For more information about this update, visit
https://www.ebi.ac.uk/pdbe/news/base-pairs-rna-secondary-structure-pdbe
https://www.ebi.ac.uk/pdbe/news/base-pairs-rna-secondary-structure-pdbe.

Kind Regards,
David Armstrong
*

--
David Armstrong
Outreach and Training Lead
PDBe
European Bioinformatics Institute (EMBL-EBI)
European Molecular Biology Laboratory
Wellcome Trust Genome Campus
Hinxton
Cambridge CB10 1SD UK

** *Dear pdb-l, We have now updated the RNA two-dimensional (2D) topology component on the PDBe pages, building on the original implementation introduced in 2022 <https://www.ebi.ac.uk/pdbe/news/rna-topology-viewer-added-pdbe-pages>. This updated component now features base pairing information, emphasising the presence of secondary structure elements like helical stems and single-stranded loops. This enhancement was developed and integrated into the PDBe RNA topology viewer by Holly McCann and Caeden Meade, collaborators from Georgia Tech. Base pairing information is generated using the open-source FR3D software <http://europepmc.org/article/MED/21515634>and incorporated into the PDBe's weekly release process with assistance from partners at Bowling Green State University (BGSU) <https://www.bgsu.edu/>.* * The open-source RNA 2D topology component, available at https://github.com/PDBeurope/pdb-rna-viewer <https://github.com/PDBeurope/pdb-rna-viewer>, presents the secondary structure in consistent, reproducible, and easily recognisable layouts using R2DT <https://nature.com/articles/s41467-021-23555-5>. Base pairing annotations are superimposed on the R2DT-generated layouts, employing the Leontis-Westhof base-pairing classification <https://europepmc.org/article/MED/11345429>. Furthermore, the component interacts with the Mol* viewer allowing features in the 2D topology component to be easily explored in 3D. For more information about this update, visit https://www.ebi.ac.uk/pdbe/news/base-pairs-rna-secondary-structure-pdbe <https://www.ebi.ac.uk/pdbe/news/base-pairs-rna-secondary-structure-pdbe>. Kind Regards, David Armstrong * -- David Armstrong Outreach and Training Lead PDBe European Bioinformatics Institute (EMBL-EBI) European Molecular Biology Laboratory Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SD UK