View protein structures alongside predicted pathogenicity scores
from AlphaMissense.

Examine missense variations within 3D protein structures.

Gain insights into the potential impact of specific residue changes
based on AlphaMissense prediction

** *Dear pdb-list,* * The AlphaFold Protein Structure Database, which provides open access to protein structure predictions, has integrated data from the AlphaMissense AI model. AlphaMissense predicts whether specific genetic variations (missense variants) are more likely to be pathogenic or benign. This integration allows researchers to: * View protein structures alongside predicted pathogenicity scores from AlphaMissense. * Examine missense variations within 3D protein structures. * Gain insights into the potential impact of specific residue changes based on AlphaMissense prediction Further Resources: AlphaFold Protein Structure Database: *https://alphafold.ebi.ac.uk/#news* <https://alphafold.ebi.ac.uk/#news> News item from EMBL-EBI: https://www.ebi.ac.uk/about/news/technology-and-innovation/alphamissense-data-integration/ We'll continue to keep you updated on advancements in this field. Sincerely, Deborah Harrus * -- ------------------------------------------------------------------- Deborah Harrus, Ph.D. PDBe Archive Project Leader, Biocuration Lead PDBe - Protein Data Bank in Europe European Bioinformatics Institute (EMBL-EBI) European Molecular Biology Laboratory Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SD UK http://www.PDBe.org -------------------------------------------------------------------