Developing strategiesto predict high-quality structure models for
large biomacromolecular complexes.

Cataloguing biomolecular interactionsin the human proteome.

Enhancing these datasets using Knowledge Graph (KG) techniquesto
provide enriched structural and functional annotations. This will
enable more efficient data interpretation and knowledge transfer
between related proteins.

Primary Location: EMBL-EBI, Cambridge, UK

Regular collaborations and visits to SciLifeLab, Stockholm,
Swedenare expected.

The position is for 3 years.

Background, proposed project

Expected results & their impact

Service to be offered

Consideration of FAIR principals

For this application

  o

    Marta Carroni <marta.carroni@scilifelab.se>

  o

    Sameer Velankar <sameer@ebi.ac.uk>

  o

    Arne Elofsson <arne@bioinfo.se>

For questions about  the ARISE2 program

  o

    arise2@embl.org

** *Dear PDB-List,* * We are excited to announce a unique postdoctoral opportunity for a STEM professional to work on cutting-edge AI applications in structural biology through the ARISE2 MSCA-funded fellowship program. Our project, led by the Elofsson and Velankar teams, aims to address computational challenges in predicting large biomacromolecular complexes using AI-based methods like AlphaFoldand RoseTTaFold. These advanced models offer transformative insights into protein structure and function, but extending their application to larger complexes (more than two subunits) requires innovative solutions. Our work will focus on: * Developing strategiesto predict high-quality structure models for large biomacromolecular complexes. * Cataloguing biomolecular interactionsin the human proteome. * Enhancing these datasets using Knowledge Graph (KG) techniquesto provide enriched structural and functional annotations. This will enable more efficient data interpretation and knowledge transfer between related proteins. The methods developed will be tested in collaboration with researchers at EMBLand SciLifeLabcryo-EM and integrative structural biology facilities, ensuring real-world applicability to a broad research community. Location and Duration * Primary Location: EMBL-EBI, Cambridge, UK * Regular collaborations and visits to SciLifeLab, Stockholm, Swedenare expected. * The position is for 3 years. Application Please send a two-page CV and a two-page project proposal within the area outlined above to Sameer Velankar at sameer@ebi.ac.ukby November 5, 2024. The two-page proposal should cover the following areas - * Background, proposed project * Expected results & their impact * Service to be offered * Consideration of FAIR principals This is a pre-proposal. In the second step, we will select one candidate by November 12 at the latest, and together with the candidate, we will submit a full proposal by the deadline for the ARISE2 call on November 25. Contacts: More information about the ARISE2 program can be found at https://www.embl.org/training/arise2/ * For this application o Marta Carroni <marta.carroni@scilifelab.se> o Sameer Velankar <sameer@ebi.ac.uk> o Arne Elofsson <arne@bioinfo.se> * For questions about  the ARISE2 program o arise2@embl.org * -- ------------------------------------------------------------------- Deborah Harrus, Ph.D. PDBe Archive Project Leader, Biocuration Lead PDBe - Protein Data Bank in Europe European Bioinformatics Institute (EMBL-EBI) European Molecular Biology Laboratory Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SD UK http://www.PDBe.org -------------------------------------------------------------------